GW29-e0055 Allicin Protect Against Cardiac Fibrosis In Model After Myocardial Infraction
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چکیده
منابع مشابه
Effects of HIIT and Curcumin Supplementation on Rat Cardiac Fibrosis Signaling Pathway Following Myocardial Infraction
Background and Objective: the aim was to investigate the effects of 12 weeks of High Intensity Interval Training (HIIT) and curcumin supplementation on expression levels of FSTL1 and Smad7 and also Type I, III and IV collagens in rat model with myocardial infraction (MI). Methodology: 48 male rats were randomized into five groups of Reference, HIIT, Curcumin, Concomitant (HIIT+ Curcumin) and Co...
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Introduction The incidence of congestive heart failure (HF) is increasing with epidemic proportions, occurring most frequently in patients with structural heart disease resulting from myocardial infarction (MI). The process of cardiac remodeling that provides the substrate for HF results from fibrotic scar formation that replaces regions of myocyte necrosis. In addition, surviving myocytes unde...
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Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure. Although dysregulation of microRNA (miRNA) is involved in various pathophysiological processes in the heart, the role of miRNA in fibrosis regulation after MI is not clear. Previously we observed the correlation between fibrosis and the miR-24 expression in hypertrophic hea...
متن کاملEndogenous S-nitrosothiols protect against myocardial injury.
Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione reductase gene (GSNOR(-/-)) have reduced myocardial infarct size, preserved ve...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2018
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2018.08.1048